Zofran (ondansetron) typically starts working within 30 minutes to 2 hours after taking a dose. The exact time it takes can vary depending on the formulation, dosage, metabolism, and individual factors.
- Orally disintegrating tablets (ODT) can work faster, usually within 15 to 30 minutes due to quicker absorption under the tongue.
- Standard oral tablets or oral solutions generally begin to take effect around 30 minutes.
- Injectable forms (IV or IM) work the fastest, usually within 15 minutes since they enter the bloodstream directly.
Overall, patients usually experience relief from nausea and vomiting within this time frame, but for optimal effectiveness, it is recommended to take Zofran before nausea symptoms start whenever possible.
