Misoprostol usually starts working about 30 minutes to a few hours after taking it. Most women start having cramps and bleeding in about 4 to 6 hours, and the expulsion of tissue may occur around 16 hours later. The bleeding and cramping can last for several hours, with the cramping easing and stopping within 4 to 7 days. Some spotting or bleeding can continue for up to 2 weeks. Heavy bleeding generally starts around 2 hours after taking misoprostol but could vary slightly. The entire process usually takes 4 to 8 hours, though it can be quicker or longer depending on the individual response and the method of administration (oral or vaginal).
