Oxycodone's effects typically last about 4 to 6 hours for immediate-release forms, while extended-release formulations can last between 8 to 12 hours. The drug reaches peak blood levels around 1 to 2 hours after ingestion for immediate-release and 3 to 4 hours for extended-release versions. The half- life of oxycodone is about 3.2 to 4.5 hours, meaning it takes that long for half the drug to be metabolized and eliminated, but it can take about 24 hours or more for the drug to be cleared from the blood. Detectability in various tests varies: oxycodone can be detected in blood up to 24 hours, saliva up to 1 to 2 days, urine around 3 to 4 days, and hair tests can detect use for up to 90 days after last dose.
Key Points on Duration and Metabolism
- Immediate-release oxycodone effects last about 4 to 6 hours.
- Extended-release oxycodone effects can last 8 to 12 hours.
- Half-life ranges from about 3.2 to 5.6 hours depending on formulation.
- Full elimination from blood usually occurs within 24 hours.
- Extended-release versions take longer to peak and clear.
Detection in Body
- Blood: Detectable up to 24 hours.
- Saliva: Up to 1 to 2 days.
- Urine: 3 to 4 days.
- Hair: Up to 90 days.
This variability depends on individual metabolism, dosage, formulation, liver function, and frequency of use.
