Panadol, which contains paracetamol, typically begins working within 20 to 30 minutes after taking it. The pain relief effect usually lasts about 4 to 6 hours. There are sustained-release formulations of Panadol (e.g., Panadol Extend or Panadol Osteo) designed for longer-lasting relief, which can provide up to 8 hours of pain relief. The exact duration can vary depending on the specific formulation and individual factors such as metabolism and dosage.