Trazodone's effects in dogs generally last between 6 to 12 hours after a single dose, though this can vary depending on the dog's size, metabolism, dosage, and overall health. Typically, it takes about 1 to 2 hours for trazodone to start working. In cases of long-term use for anxiety management, it may take 2 to 4 weeks to reach full efficacy. The medication is metabolized by the liver and kidneys, so dogs with liver or kidney issues may experience longer-lasting effects. Usually, a single dose should wear off completely within 24 hours. Here is a summary of key points about trazodone duration in dogs:
- Onset of action: about 1-2 hours after administration.
- Duration of effect: typically 6-12 hours.
- Full clearance: within 24 hours after one dose.
- Long-term treatment: full effects may take 2 to 4 weeks.
- May last longer in dogs with liver or kidney disease.
These estimates are for therapeutic doses used to manage anxiety or stress in dogs.
