Tylenol (acetaminophen) typically provides pain relief and fever reduction for about 4 to 6 hours after taking a regular or extra strength dose
. Extended-release formulations of Tylenol can prolong the effect to about 8 hours
. The onset of action varies by formulation:
- Dissolvable powders and liquids start working in about 15 to 20 minutes.
- Rectal suppositories take about 10 to 15 minutes.
- Intravenous acetaminophen acts within 5 to 10 minutes
Factors influencing how long Tylenol lasts include the dose taken, individual metabolism, liver function, whether it is taken with food, and the specific formulation used
. The half-life of acetaminophen in the body is generally 1 to 4 hours, and the drug is metabolized mainly by the liver
. For adults, the usual dosing for Extra Strength Tylenol is 1 to 2 tablets every 6 hours as needed, not exceeding 6 tablets in 24 hours
. In summary:
- Regular Tylenol lasts about 4 to 6 hours.
- Extended-release Tylenol lasts about 8 hours.
- Onset is typically within 15-20 minutes for oral forms.
- Duration may vary based on individual factors and formulation
