Tylenol (acetaminophen) generally takes about 20 to 45 minutes to start working, depending on the form taken and whether it is taken on an empty stomach. Liquid and dissolving tablets work fastest, typically within 20 minutes, while regular tablets usually take 30 to 45 minutes to provide relief. The pain relief effect usually lasts for about 4 to 6 hours. Extended- release formulations may take slightly longer to kick in but last longer.
Factors Influencing Onset
- Formulation: Liquids and dissolving tablets act faster than regular or extended-release tablets.
- Food intake: Taking Tylenol on an empty stomach speeds up absorption and onset.
- Individual factors: Age, body weight, metabolism, and overall health can affect how fast Tylenol works.
Duration of Effect
- Regular Tylenol provides relief for about 4 to 6 hours.
- Extended-release versions may last closer to 8 hours.
Summary Table
Tylenol Formulation| Typical Onset Time| Duration of Effect
---|---|---
Liquid / Dissolving tablets| ~20 minutes| 4 to 6 hours
Regular tablets| 30 to 45 minutes| 4 to 6 hours
Extended-release tablets| 30 to 60 minutes| Up to 8 hours
Rectal suppositories| 10 to 15 minutes| Varies
Intravenous (hospital use)| 5 to 10 minutes| Varies
This timing helps set expectations for when pain relief or fever reduction will start after taking Tylenol.
