Hand, foot, and mouth disease (HFMD) is most contagious during the first week of illness, especially during the first few days when a fever is present. However, the virus can continue to be spread for several weeks after symptoms have improved because it remains in bodily fluids such as stool for an extended period. Typically, HFMD is contagious for about 7 to 10 days, but the virus can be shed in stool for weeks or even months after symptoms disappear. It's advised to stay home until the fever has been gone for at least 24 hours and blisters have dried to reduce transmission risk. Good hygiene practices are essential to prevent spreading the virus further.