Chicken breast in a slow cooker typically takes between 1 to 3.5 hours on a low setting, depending on the size and thickness of the breasts. Generally, for boneless, skinless chicken breasts, it takes about 2.5 to 3 hours on low to reach the safe internal temperature of 165°F (74°C). On a high setting, cooking takes about 1 to 2.5 hours. Bone-in breasts require about an additional hour compared to boneless ones. Cooking on low is preferred to keep the meat tender and juicy, while cooking on high can dry the chicken out unless submerged in liquid. Always use a meat thermometer to ensure doneness.