James Conner will be out for the rest of the 2025 NFL season due to a severe right ankle injury. He suffered this injury during the Arizona Cardinals' Week 3 game against the San Francisco 49ers and will undergo ankle surgery. His season-ending status was confirmed by multiple sources including ESPN and NFL insiders. The injury is described as gruesome and severe enough to require surgery, with no timetable given for a return this season. As a result, Conner is expected to miss all remaining games in 2025.
