George Kittle is expected to be out for at least four weeks due to a hamstring injury suffered in Week 1 of the 2025 NFL season. He was officially placed on injured reserve by the San Francisco 49ers, which mandates missing a minimum of four games. His projected recovery timeline is estimated between three to five weeks. The earliest he could return to play would be in Week 6 when the 49ers face the Tampa Bay Buccaneers, though it is uncertain if he will be ready by then. During his absence, backup tight ends Jake Tonges and Luke Farrell are expected to fill in.