The safe dosage of naproxen depends on whether it is taken over-the-counter (OTC) or by prescription, and the specific condition being treated.
Safe Dosage Guidelines
- Over-the-Counter Naproxen (e.g., Aleve):
- Standard OTC naproxen tablets contain 220 mg of naproxen.
- Adults should take one pill every 8 to 12 hours as needed.
- Do not exceed 3 pills (660 mg) in 24 hours.
- If pain is not relieved by one pill, two pills may be taken within the first hour, but no more than two pills in any 8 to 12-hour period
- Prescription-Strength Naproxen:
- Available in 250 mg, 375 mg, and 500 mg tablets.
- Typical recommended dose is 250 mg to 550 mg twice a day.
- Maximum daily dose should not exceed 1,100 mg to 1,375 mg depending on the source.
- For some acute conditions like gout attacks, an initial dose of 750 mg may be given, followed by 250 mg every 8 hours until relief
- Maximum Daily Limits:
- For general use, do not exceed 1,000 mg per day (500 mg twice daily) is a common recommendation to avoid side effects.
- Some sources allow up to 1,375 mg per day for short periods.
- The NHS notes for painful periods, do not exceed 1,250 mg in 24 hours
Important Safety Notes
- Taking more than the recommended dose increases risks of gastrointestinal issues (like bleeding), kidney damage, and cardiovascular events such as heart attacks and strokes
- Naproxen interacts with blood thinners and some blood pressure medications, so consult a doctor if you are on such treatments
- Use the lowest effective dose for the shortest time possible to minimize risks
Summary
Formulation| Typical Dose| Max Daily Dose
---|---|---
OTC Naproxen (220 mg)| 220 mg every 8-12 hours| 660 mg (3 pills)
Prescription Naproxen| 250-550 mg twice daily| 1,100-1,375 mg
Painful Periods (NHS)| Up to 1,250 mg daily| 1,250 mg
Always follow package instructions or your doctor’s advice, and do not exceed recommended doses to avoid serious side effects
