Motrin (ibuprofen) can generally be taken every 4 to 6 hours as needed for pain or fever. The typical adult dose is 200 to 400 mg per dose. Do not exceed 1200 mg in a 24-hour period for over-the-counter use. Under medical supervision, the dose can be higher, up to 3200 mg daily. It is important not to take it more frequently than every 4 hours to avoid side effects such as stomach problems or kidney issues. Always follow the product label or a doctor's instructions and take it with food to reduce stomach irritation.