Bitcoin's difficulty adjustment mechanism typically occurs every 2,016 blocks, which corresponds to roughly every two weeks. This adjustment is designed to maintain an average block creation time of about 10 minutes regardless of the number of miners or total computational power on the network. If blocks are being mined faster than expected, the difficulty increases; if slower, the difficulty decreases. This self-regulating mechanism ensures the stability and security of the Bitcoin network by adapting to changes in the network's hash rate.