The HPV vaccine is typically given as either a two-dose or three-dose series depending on the age at which vaccination is started:
- For most individuals starting the vaccine before their 15th birthday, a two-dose series is recommended. The second dose is given 6 to 12 months after the first dose. If the second dose is given less than 5 months after the first, a third dose may be needed.
- For those starting the vaccine at age 15 through 26 years, or for immunocompromised persons, a three-dose series is recommended. The schedule for these three doses is at 0, 1–2, and 6 months.
- Adults aged 27 through 45 years may also receive the vaccine after discussion with a healthcare provider; the same three-dose schedule usually applies for immunocompromised individuals in this age range.
HPV vaccination is generally recommended to start at age 11 or 12 but can be started as early as age 9. The vaccine series is not generally recommended for most people over 26 years old except in certain cases as advised by a clinician. Booster doses are currently not indicated, as the protection from the initial series is long-lasting. In summary, the frequency of getting the HPV vaccine involves a one-time series of 2 or 3 doses depending on age and immune status:
- 2 doses spaced 6-12 months apart for ages 9-14.
- 3 doses at 0, 1-2, and 6 months for ages 15-26 and immunocompromised persons.
- Possible vaccination in ages 27-45 based on individual risk assessment.
This guidance is consistent with recommended schedules as of 2025 by CDC and other health authorities.
