The best time to send a thank-you email after an interview is within 24 hours. This timing keeps you fresh in the interviewer's mind while showing promptness, enthusiasm, and seriousness about the position. Sending the email ideally within an hour or a few hours after the interview is fine, but waiting up to 24 hours is optimal to write a calm and thoughtful note. Sending a thank-you email up to 48 hours after the interview is still acceptable, but beyond 72 hours it loses its significance. If the interview takes place on a Friday, sending the note that same evening or by Monday/Tuesday is recommended to avoid weekend delays. This approach demonstrates appreciation, reinforces interest, and helps maintain a positive impression with the interviewer.