Tylenol (acetaminophen) is generally considered safe for use during pregnancy when taken at the lowest effective dose and for the shortest possible duration. Medical experts and organizations, including the American College of Obstetricians and Gynecologists (ACOG), continue to recommend acetaminophen as the safest pain reliever for pregnant women for treating pain and fever. There is no firm evidence that acetaminophen use during pregnancy causes autism or other neurodevelopmental disorders in children, according to multiple large studies conducted up to 2025. However, caution is advised to avoid prolonged or high-dose use, and pregnant women should consult their healthcare provider before taking it. Recent discussions in 2025 have highlighted some concerns raised by President Donald Trump regarding a possible link between prenatal acetaminophen use and autism, but these claims are not supported by conclusive scientific evidence. The FDA plans to update safety labels and provide guidance to physicians for judicious use of acetaminophen in pregnancy. Overall, acetaminophen remains the recommended and safest choice for pain relief during pregnancy compared to other medications like ibuprofen, which are not advised for pregnant women. In summary, Tylenol is safe during pregnancy with proper medical guidance, particularly to manage pain and fever, while avoiding unnecessary prolonged use or high doses.