The main cast of the original animated series "Kim Possible" (2002–2007) includes:
- Christy Carlson Romano as Kim Possible, a confident high school student and crime-fighter.
- Will Friedle as Ron Stoppable, Kim's sidekick and childhood best friend.
- Nancy Cartwright as Rufus, Ron's pet naked mole-rat.
- Tahj Mowry as Wade Load, a teenage computer genius and inventor.
- John DiMaggio as Dr. Drakken, a mad scientist and Kim's archenemy.
Additional cast members include Nicole Sullivan, Kirsten Storms, Jean Smart, and Patrick Warburton in various recurring roles. Romano and Friedle were noted for their chemistry, which was a key factor in the show's success. For the 2019 live-action TV film adaptation, the main cast includes:
- Sadie Stanley as Kim Possible.
- Sean Giambrone as Ron Stoppable.
- Ciara Riley Wilson as Athena, a new student and skilled bōjutsuka.
- Taylor Ortega as Shego.
- Todd Stashwick as Drakken.
- Alyson Hannigan as Dr. Ann Possible, Kim's mother.
- Matthew Clarke as James Timothy Possible, Kim's father.
- Isaac Ryan Brown as Wade.
- Nancy Cartwright reprising Rufus.
- Christy Carlson Romano appearing as a pop star in a cameo role.
These are the principal cast members for both the original animated series and the live-action adaptation of Kim Possible.
