many cell organelles, most notably the nucleus, are anchored by which are assembled from a diverse class of proteins.

Many cell organelles, most notably the nucleus, are anchored by the cytoskeleton, which is assembled from a diverse class of proteins. The cytoskeleton includes actin filaments, microtubules, and intermediate filaments that mechanically support the cell, maintain its shape, and position organelles correctly within the cytoplasm. Specifically for the nucleus, a protein complex called LINC (Linker of Nucleoskeleton and Cytoskeleton) plays a key role. This complex includes proteins with SUN and KASH domains that bridge the inner and outer nuclear membranes, connecting the nucleus to the cytoskeleton. The nucleoskeleton side includes lamin proteins forming the nuclear lamina inside the nucleus, while the cytoplasmic side interacts with cytoskeletal components, anchoring the nucleus in place. The ANC-1 protein (orthologous to Nesprin1/2 in mammals) is critical for positioning the nucleus and other organelles such as mitochondria and the ER, acting as an anchoring protein that links organelles to the cytoskeletal network. Thus, the cytoskeleton and associated proteins like those of the LINC complex and ANC-1/Nesprin family are essential for anchoring organelles including the nucleus by assembling a dynamic structural network within the cell.