Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) used primarily to treat pain and inflammation associated with various types of arthritis, including osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis. It works by reducing the production of substances in the body that cause pain, inflammation, and fever. Meloxicam helps relieve symptoms such as pain, swelling, stiffness, and tenderness in the joints. It is available in several forms, including oral tablets, capsules, suspension (liquid), and intravenous injection. Meloxicam is often taken once daily and is known for its longer half-life compared to other NSAIDs, allowing convenient once-daily dosing. Common side effects include abdominal pain, dizziness, swelling, headache, and rash. Serious side effects may involve heart disease, stroke, kidney problems, and stomach ulcers. Its use is generally recommended at the lowest effective dose for the shortest duration necessary. Meloxicam belongs to the oxicam family of chemicals and works by preferentially inhibiting the enzyme cyclooxygenase-2 (COX-2), which plays a significant role in inflammation. It was patented in 1977, approved for medical use in the United States in 2000, and is available both as a brand-name drug (e.g., Mobic) and generic medication. An intravenous form was approved in 2020. Meloxicam is widely prescribed for managing arthritis-related symptoms in both adults and children over age 2 years.
