The main cast of "Murder in a Small Town" includes:
- Rossif Sutherland as Detective Karl Alberg
- Kristin Kreuk as Cassandra Lee
- Mya Lowe as Corporal Edwina Yen
- Aaron Douglas as Sergeant Sid Sokolowski
- Savonna Spracklin as Isabella Harbud
- Fritzy-Klevans Destine as Constable Andy Kendrick
- Fiona Vroom as Phyllis Diaz
- Dakota Guppy as Holly Alberg
- Paloma Kwiatkowski as Bree
- Gardiner Millar as Callum Hingle
- Crystal Balint as Dr. Olive Duval
- Alisha Newton as Devon Travis
- James Cromwell as George Wilcox
- Jonathan Whitesell as Riley Erlandson
- Tammy Gillis as Bronwen Travis
- Aaron Pearl as Kenny Mac
- Marcia Gay Harden as Mayor Christie Holman (season 2)
- Bethany Brown as Corporal Laila Jackson (season 2)
- Notable guest stars include Stana Katic, Devon Sawa, Erica Durance, Paula Patton, and more.
The show centers around Detective Karl Alberg moving to a small coastal town and solving murders there, with a growing romance subplot between Alberg and librarian Cassandra Lee.
