To avoid fatigue during CPR, team roles that provide chest compressions should alternate every 2 minutes or after about 5 cycles of compressions. This timing helps maintain effective compressions and reduces rescuer fatigue. Switching roles more frequently than this may disrupt the flow, while switching less often risks fatigue, which can decrease the quality of compressions. This guideline is widely recommended for maintaining CPR effectiveness and rescuers' endurance during resuscitation efforts.