In the event of a skyjacking, it is generally not recommended to immediately attempt to subdue the skyjackers as this could escalate the situation and endanger the lives of passengers and crew. Instead, the recommended approach is to remain calm, comply with the hijackers' demands if necessary, and let trained authorities handle the situation. However, there have been incidents where passengers and crew actively intervened to subdue hijackers, but these situations are exceptional and involve high risk. Flight crews are often trained to be vigilant and respond appropriately, but widespread guidance tends to favor compliance and de-escalation to maximize safety until help arrives.
In summary, the statement "In the event of a skyjacking, you should immediately attempt to subdue the skyjackers" is False under typical safety protocols and guidance.