The alcohol in a margarita is tequila. Margaritas are typically made with high-quality blanco tequila, which is made from 100% blue agave. In addition to tequila, margaritas also contain lime juice and orange liqueur, such as Cointreau, Grand Marnier, or Triple Sec. Some variations of the classic margarita recipe may use agave syrup instead of orange liqueur. The alcohol content of a margarita can vary depending on the recipe, but the average alcohol content is around 18-25% .