Some antidepressants can cause weight loss as a side effect, although this is not a common occurrence. The following antidepressants have been associated with weight loss:
- Bupropion (Wellbutrin) : This antidepressant can lead to a decrease in appetite and slight weight loss during the first months of treatment. It works by blocking norepinephrine and dopamine, which may have an effect on weight
- Fluoxetine (Prozac) : A 2022 review found that taking 60 milligrams (mg) of fluoxetine daily can lead to an average weight loss of 2.7 kilograms (kg) in adults with overweight or obesity. However, there is no weight loss effect for people taking low dosages for a longer duration
- Duloxetine (Cymbalta) : This antidepressant has also been associated with a decrease in appetite and slight weight loss
Weight gain is a more common side effect of antidepressants than weight loss. Factors such as lifestyle adjustments, emotional eating, and the specific drug class and type can influence weight changes
. It is essential to consult with a healthcare professional to discuss the potential side effects and benefits of antidepressants for weight loss. Additionally, lifestyle adjustments, such as regular exercise and a balanced diet, can help minimize weight changes caused by antidepressants
