what best describes the term drug tolerance?

The best description of the term "drug tolerance" is that it is the diminished response to a drug, alcohol, or other substance over repeated or prolonged exposure. This means that over time, the body becomes accustomed to the drug, requiring increasingly larger doses to achieve the same effect that was initially experienced. Drug tolerance is a physiological adaptation in which the body or brain responds less to the drug at a given dose, leading to reduced effectiveness and often necessitating dosage increases for the same therapeutic or psychoactive effect.