For a sore throat during pregnancy, safe options include natural home remedies and certain over-the-counter medications with caution. Simple remedies such as gargling warm salt water several times a day, drinking ginger tea with lemon (in moderation), and consuming foods rich in vitamin C can help soothe the throat and boost immunity without harm to the baby. Additionally, sucking on ice chips or specific throat lozenges approved for pregnant women may relieve pain. Over-the-counter medications considered generally safe for sore throat relief during pregnancy include acetaminophen (Tylenol) for pain, and throat sprays or lozenges containing benzocaine or menthol. Antihistamines like Benadryl may be used if allergies contribute to the sore throat. It is important to avoid certain herbs like sage or thyme in gargles as they could induce contractions. If symptoms are severe, persistent, or accompanied by high fever, difficulty swallowing, or pus, it is essential to consult a healthcare provider for proper diagnosis and treatment. Antibiotics like penicillin or cephalosporins can be given if there is a bacterial infection, but only under medical supervision. In summary, warm salt water gargles, hydration, vitamin C-rich foods, safe herbal teas, ice chips, some throat lozenges, and acetaminophen are good options to relieve a sore throat while pregnant, with medical advice for any medication use or worsening symptoms.