The exact cause of cluster headaches is unknown, but researchers have identified some factors that may trigger them. According to the search results, the hypothalamus, a small area deep in the brain that modulates several neurobiological systems, has been shown to be activated during cluster attacks. The hypothalamus is also linked to the bodys biological clock, which controls sleep and wake cycles. Other triggers of cluster headaches include alcohol use or smoking cigarettes, change to a high altitude, bright light, exercise or exertion, heat, foods that contain nitrates, such as bacon or lunch meat, and cocaine use. Cluster headaches may also be related to the sudden release of histamine or serotonin in the body. More men than women are affected, and the headaches can occur at any age, but are most common in the 20s through middle age. They tend to run in families.