High bilirubin levels, known as hyperbilirubinemia, can be caused by various factors, including liver or bile duct disorders, and can manifest with jaundice. Bilirubin is a waste product of expired red blood cells, and high levels of bilirubin in the blood may indicate different types of liver or bile duct problems. Common causes of high bilirubin levels include liver disease, hepatitis, alcoholic liver disease, and hemolytic anemia. High bilirubin levels can cause jaundice, which is characterized by a yellowish color in the eyes and skin. Other symptoms of illnesses that cause high bilirubin levels can include nausea, vomiting, stomach pain, bloating, unintentional weight loss, headaches, confusion, fatigue, and drowsiness