Restless leg syndrome (RLS) is a neurological disorder that causes an uncontrollable urge to move the legs, usually because of an uncomfortable sensation. The exact cause of RLS is not well understood, but researchers suspect that it may be caused by an imbalance of the brain chemical dopamine, which is used by the basal ganglia to regulate movement. Some cases of RLS are believed to be inherited, and specific gene variants have been associated with the condition. Other factors that may contribute to RLS include:
- Chronic diseases, such as iron deficiency, Parkinsons disease, kidney failure, diabetes, and peripheral neuropathy
- Nerve damage in the legs from diabetes, kidney problems, or other underlying health conditions
- Certain medications, such as antidepressants, antipsychotics, and antihistamines
RLS can affect anyone, but it is more common in women and middle-aged people. There is no specific test for RLS, so the condition is diagnosed by a doctors evaluation based on the five basic criteria for clinically diagnosing RLS. While there is no cure for RLS, treatment options are available to help relieve symptoms, including medications and lifestyle changes.
