Syphilis is an infection caused by the bacterium Treponema pallidum. It is most often spread through sexual contact, including vaginal, oral, or anal sex. The disease starts as a painless sore that typically appears on the genitals, rectum, or mouth. Syphilis can also be passed from a mother to her baby during pregnancy and childbirth, and sometimes through breastfeeding. Without treatment, syphilis can damage the heart, brain, or other organs, and it can be life-threatening. The infection can stay in the body for many years without causing symptoms, but it can become active again. Early syphilis can be cured, sometimes with a single shot of penicillin