The exact cause of ulcerative colitis is unknown, but it is believed to be the result of a problem with the immune system. Ulcerative colitis is an inflammatory bowel disease that causes chronic inflammation and ulcers in the superficial lining of the large intestine, also called the colon. It is estimated that about a million Americans are living with ulcerative colitis, making it the most common form of inflammatory bowel disease. Some experts believe that ulcerative colitis is an autoimmune condition, where the immune system mistakenly attacks healthy tissue. Genetics may also play a role, and you are at higher risk if a first-degree relative has it. Environmental factors may also be important, and it is believed that various factors such as air pollution, diet, and stress may be linked to ulcerative colitis. Research suggests that ulcerative colitis could be triggered by an interaction between a virus or bacterial infection in the colon and the body’s immune response.