For Week 5 in the NFL 2025 season, top defense pickups to consider based on matchups and recent performance are:
- Minnesota Vikings against the Browns (London game): The Vikings defense is strong and the Browns offense struggles with giveaways and sacks allowed, making Vikings a top streaming option.
- Arizona Cardinals versus the Titans: The Titans offense is one of the worst in the league, and the Cardinals defense has been respectable with sacks and turnovers. This matchup makes the Cardinals a strong choice.
- Indianapolis Colts at home versus the Raiders: The Colts defense, although knocked around in a recent loss, is otherwise solid. The Raiders quarterback Geno Smith has struggled with interceptions and sacks, making the Colts a viable option.
- New York Giants against the Saints: The Giants defense is very weak overall but gets a favorable matchup versus the Saints offense, which is also struggling. The Giants pass rush has notable players who may generate fantasy production.
- Miami Dolphins against the Panthers: While not strong overall, the Dolphins face a weak Panthers offense, making them a budget streaming consideration.
Additional notable defenses for Week 5 include the Browns, Lions, Rams, Bills, and Giants, all having favorable matchups. Summary table of recommended Week 5 defenses:
Defense| Opponent| Notes
---|---|---
Minnesota Vikings| Browns (London)| Strong matchup, Browns offense turnover-
prone
Arizona Cardinals| Titans| Titans offense very weak, Cardinals respectable
Indianapolis Colts| Raiders| Raiders QB turnover issues, Colts solid defense
New York Giants| Saints| Giants pass rush can exploit struggling Saints
Miami Dolphins| Panthers| Budget option, weak Panthers offense
These picks offer a good balance of matchup advantage and recent defensive performance for fantasy football or other NFL defense-focused selections in Week 5 2025.
