Alka-Seltzer tablets are a combination medication that contains three active ingredients: aspirin, sodium bicarbonate, and anhydrous citric acid. They are effervescent antacids and pain relievers that work to relieve symptoms of indigestion, upset stomach, heartburn, acid indigestion, and stomach aches. The sodium bicarbonate in the tablets acts as an antacid, while the aspirin is a pain reliever and anti-inflammatory. The citric acid reacts with the sodium bicarbonate and water to form effervescence, which helps the medicine dissolve fast and go to work instantly, neutralizing acid on contact. Alka-Seltzer tablets are taken orally and are dissolved in water before use. They are available in various flavors and are marketed for relief of minor aches, pains, inflammation, fever, headache, heartburn, stomachache, indigestion, acid reflux, and hangovers.