"What Do You Meme?" is an adult party game where players compete to create the funniest memes by pairing caption cards with a photo card in play. The game is designed for people 17 and older and is not suitable for younger children due to mature language and references. The rules are simple: each player draws seven caption cards, a designated photo card is chosen for the round, and a rotating judge picks the funniest meme combination. The player with the most photo cards at the end of the game wins. The game is typically played with three or more people, but there are alternative ways to play with just two people, such as drawing random cards and mixing them in with the players' choices.