The "A & M" in Texas A&M originally stands for "Agricultural and Mechanical." It reflects the university's origins as the Agricultural and Mechanical College of Texas when it was founded in 1876. Although today the letters "A & M" are primarily symbolic and don't literally stand for those words anymore, they honor the institution's past as a land-grant college focused on agriculture, military tactics, and mechanical arts education.
So, "A & M" is an abbreviation for Agricultural and Mechanical.