Nick Bosa, the star edge rusher for the San Francisco 49ers, suffered a torn ACL in his right knee during a game against the Arizona Cardinals on September 21, 2025. This injury is season-ending, and he will need surgery, ruling him out for the remainder of the 2025 NFL season. It is the second time Bosa has torn the ACL in the same knee, having previously sustained a similar injury in 2020. Prior to this injury, Bosa had a strong start to the season with two sacks in the first three games. His absence creates a significant challenge for the 49ers' pass rush and defensive scheme moving forward, as depth at his position becomes a concern.