Direct answer: A UPS MD-11 cargo aircraft (UPS Airlines Flight 2976) crashed shortly after takeoff from Louisville Muhammad Ali International Airport on November 4, 2025, en route to Honolulu. Initial reports indicated a devastating fire and a large number of casualties, including both crew and people on the ground; the death toll rose as investigations progressed, with authorities confirming multiple fatalities and numerous injuries. The crash prompted a shelter-in-place and extensive emergency response around the airport and nearby areas, and investigators from the FAA and NTSB (and local authorities) began examining the scene to determine the cause.
If you’d like, I can summarize the latest official findings from authorities as they become available, or provide a timeline of events and known details as reported by reputable outlets.
