"What" in Spanish can be translated in various ways depending on the context. Some common translations include "qué," "cuál," "lo que," and "cómo". "Qué" is the most common translation and is used in direct questions, while "cuál" is used when asking for a choice or preference. "Lo que" is used to mean "that which" or "whatever," and "cómo" is used to ask about the manner or way in which something is done. It is important to note that "lo qué" is a vulgarism and should be avoided.