Dandadan is about two high school teenagers, Momo Ayase and Ken Takakura (nicknamed Okarun), who have opposing beliefs about the supernatural—Momo believes in ghosts but not aliens, while Ken believes in aliens but not ghosts. To settle their differing views, they each visit locations linked to aliens and the occult, only to find that both ghosts and extraterrestrials exist. Momo gains psychic powers after an alien abduction unblocks her chakras, and Ken becomes possessed by a spirit that helps him awaken supernatural abilities. Together, they fight yōkai, spirits, and aliens, while developing romantic feelings and teaming up with various allies. The story involves action, supernatural battles, comedy, and romance, with central arcs including Ken's quest to retrieve his missing testicles ("kintama") and a mysterious curse affecting Momo that shrinks her physical presence and erases her from others' memories, driving a major part of the ongoing plot.