Desloratadine is an antihistamine medication used to relieve allergy symptoms such as sneezing, runny nose, itching eyes/nose, watery eyes, and hives. It works by blocking histamine, a substance in the body that causes allergic symptoms. Desloratadine is used to treat hay fever and hives of the skin. It comes in various forms, including tablets, oral solution (liquid), and orally disintegrating tablets, and is usually taken once a day with or without food. The medication should be taken exactly as directed by a doctor or pharmacist, and patients should not take more or less of it or take it more often than prescribed. Desloratadine does not usually cause drowsiness when used at recommended doses, but patients should not drive, use machinery, or do any activity that requires alertness until they are sure they can perform such activities safely.