what is haemophilia disease

11 months ago 22
Nature

Hemophilia is a rare genetic blood disorder that affects the bloods ability to clot properly, leading to an increased risk of bleeding or bruising. It is usually inherited and caused by a mutation or change in one of the genes that provide instructions for making the clotting factor proteins needed to form a blood clot. Hemophilia is classified by the type of clotting factor that is low, with Hemophilia A and Hemophilia B being the most common types. Hemophilia A is caused by a lack or decrease of clotting factor VIII, while Hemophilia B is caused by a lack or decrease of clotting factor IX. Hemophilia is inherited in an X-linked recessive manner, meaning that males are more likely to be affected than females. Symptoms of hemophilia include prolonged bleeding or oozing following an injury, surgery, or having a tooth extracted. The best way to treat hemophilia is to replace the missing blood clotting factor so that the blood can clot properly, which is done by infusing commercially prepared factor concentrates. People with hemophilia can learn how to perform these infusions themselves so that they can stop bleeding episodes.