The phrase "What is her problem?" is generally used to ask what is wrong with a woman or why she is behaving in an unreasonable or difficult manner. It is often an informal or rhetorical question used when someone seems upset, confused, or acting in a way that is hard to understand. It can mean simply "What issue is she facing?" or "Why is she acting this way?" depending on the context.
In informal or rhetorical usage, the phrase can imply frustration or confusion about someone's behavior rather than a literal medical or psychological problem.
If there is a specific context or example in mind, the interpretation might vary, but broadly it is a way to inquire about the cause of someone's troubling behavior or condition.