Hybridization in chemistry refers to the concept of mixing atomic orbitals to form new hybrid orbitals suitable for the pairing of electrons to form chemical bonds in valence bond theory. This process helps to explain molecule shape and bonding in various compounds. Hybridization is an integral part of organic chemistry and is used to understand the formation of bonds, bond energies, and bond lengths. The concept of hybridization is an extension of the valence bond theory and is crucial for understanding atomic bonding properties and molecular geometry. In genomics, hybridization refers to the process in which two complementary single-stranded DNA and/or RNA molecules bond together to form a double-stranded molecule, which is important in various research and clinical laboratory techniques.