Leptin resistance is a condition where the body does not respond properly to the hormone leptin, which is released by fat cells and helps regulate hunger and energy expenditure. When a person is leptin-resistant, their brain does not receive the signal from leptin that indicates the body has enough fat stored, leading to increased hunger and reduced energy expenditure. This can contribute to overeating and weight gain, as the body continues to store fat despite having sufficient fat reserves.
Leptin resistance can be caused by various factors, including inflammation, elevated free fatty acids, and high leptin levels, all of which are often associated with obesity. It is also suggested that leptin resistance may be reversible, but it requires significant diet and lifestyle changes.
In summary, leptin resistance can lead to increased food intake and decreased energy use, contributing to obesity and making weight loss more challenging. While there is ongoing research to better understand and address leptin resistance, making long-term lifestyle changes may help improve the quality of life for individuals with this condition.
