Libido in males refers to their sex drive or the desire for sex, and it can vary dramatically from one person to another. It is influenced by a symbiotic relationship between hormones and neurotransmitters, including testosterone, dopamine, serotonin, and glutamate. Many men experience changes in their sexual drive over the course of their lives, and it is normal for sexual interest to wax and wane intermittently. Factors such as age, hormone levels, medications, lifestyle, relationship problems, and underlying medical conditions can affect libido. Decreased libido in men can be caused by conditions such as hormone changes, impotence, premature ejaculation, and treatment for underlying medical conditions. Low libido may be a sign of underlying medical conditions, and evaluation by a physician may be necessary for persistent or recurrent lack of interest in sex that is troubling. Treatment for low libido in men may include addressing underlying medical conditions, hormone therapy, stress management, counseling, and psychologic counseling. Additionally, natural methods such as managing anxiety, taking herbal supplements, and maintaining a healthy diet can help boost libido. Its important to foster open and honest communication between the man with low libido and his partner, as well as seek help from healthcare professionals if needed.