PEP stands for post-exposure prophylaxis, which is a treatment that can prevent HIV after a possible exposure. It involves taking a series of pills that contain antiretroviral medications (ART) to stop HIV from spreading through the body. PEP should be used only in emergency situations and must be started within 72 hours of possible exposure to HIV. It is highly effective in preventing HIV if taken within 72 hours after possible exposure. However, it is not a substitute for regular use of other HIV prevention methods. PEP is not the right choice for people who may be exposed to HIV frequently. If you are at ongoing risk for HIV, such as through repeated exposures to HIV, talk to your health care provider about PrEP (pre-exposure prophylaxis). PEP is safe but may cause side effects like nausea in some people. In almost all cases, these side effects can be treated.