PEPFAR stands for the U.S. Presidents Emergency Plan for AIDS Relief, which is the largest commitment by any nation to address a single disease in history. It was established in 2003 by President George W. Bush to address the global HIV/AIDS epidemic and help save the lives of those suffering from it. The purpose of PEPFAR is to expand access to HIV prevention, treatment, and care interventions, including provision of antiretroviral treatment, pre-exposure prophylaxis, voluntary male circumcision, condoms, and other commodities related to HIV services. PEPFAR is managed and overseen by the U.S. Department of State's Office of the U.S. Global AIDS Coordinator and Health Diplomacy, and it is implemented by seven other U.S. government departments and agencies. PEPFAR has saved more than 25 million lives and dramatically improved health outcomes in more than 55 partner countries.