Reglan, which contains the generic drug metoclopramide, is primarily used to treat the following conditions:
- Gastroesophageal reflux disease (GERD), particularly to relieve heartburn and promote healing of ulcers and sores in the esophagus when other treatments have not been effective.
- Gastroparesis (slow stomach emptying), especially in people with diabetes, to relieve symptoms such as nausea, vomiting, heartburn, loss of appetite, and feeling of fullness after meals.
- Prevention of nausea and vomiting associated with chemotherapy, surgery, and certain medical procedures.
Reglan works by increasing muscle contractions in the upper digestive tract, which speeds up the movement of food through the stomach and intestines. It also blocks dopamine receptors that help prevent nausea and vomiting, while aiding in keeping the lower esophagus closed to prevent acid reflux. It is usually prescribed for a short duration (4 to 12 weeks) due to potential serious side effects related to long-term use. It is available in oral and injectable forms. In summary, Reglan is used to treat acid reflux and related esophageal issues, diabetic gastroparesis, and to prevent nausea and vomiting caused by various medical conditions and treatments. It can also be used off- label for other purposes such as treating acute migraine nausea and hyperemesis gravidarum during pregnancy under medical supervision. This comprehensive use profile is supported by multiple medical sources including MedlinePlus, Drugs.com, Cleveland Clinic, Mayo Clinic, and others.
