The best antibiotic for a tooth infection typically depends on the patient's allergy status and the severity of the infection. The most commonly recommended first-line antibiotic is amoxicillin , a penicillin-type antibiotic effective against many bacteria causing dental infections. The usual dose is 500 mg three times daily for 3 to 7 days
. If the patient is allergic to penicillin, alternatives include:
- Clindamycin (300 mg four times daily for 3 to 7 days)
- Azithromycin (loading dose 500 mg on day 1, then 250 mg daily for 4 days)
- Cephalexin (for mild penicillin allergy, 500 mg four times daily)
For more severe or spreading infections, combination therapy with metronidazole (400 mg three times daily) plus amoxicillin may be used to cover anaerobic bacteria
. Important considerations:
- Antibiotics are recommended only if there is evidence of spreading infection, systemic symptoms, or high risk of complications; local drainage or dental treatment (e.g., root canal, extraction) is essential for cure
- Always complete the full prescribed antibiotic course to prevent resistance and recurrence
- Inform your dentist about any allergies or medical conditions to ensure safe antibiotic choice
In summary, amoxicillin is the best initial antibiotic for most tooth infections unless contraindicated by allergy, in which case clindamycin or azithromycin are preferred alternatives. Antibiotics alone do not cure the infection; dental intervention is necessary
